Hydrochloric Acid → 2,4-Bis(trifluoromethyl)benzaldehyde

HRID 942112Notes

Reaction equation

HRID 942112 reaction equation
[CH2:11]([Li:12])[CH2:13][CH2:14][CH3:15].[CH3:1][C:2]1([CH3:3])[CH2:4][CH2:5][CH2:6][C:7]([CH3:8])([CH3:9])[NH:10]1.[CH3:30][N:31]([CH:32]=[O:33])[CH3:34].[CH3:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46].[ClH:35].[F:16][C:17]([c:18]1[cH:19][c:20]([C:24]([F:25])([F:26])[F:27])[cH:21][cH:22][cH:23]1)([F:28])[F:29].[O:36]1[CH2:37][CH2:38][CH2:39][CH2:40]1>>[F:16][C:17]([c:18]1[cH:19][c:20]([C:24]([F:25])([F:26])[F:27])[cH:21][cH:22][c:23]1[CH:32]=[O:33])([F:28])[F:29]

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 8058HexaneHCID 130352,2,6,6-TetramethylpiperidineHCID 223106Benzene, 1,3-bis(trifluoromethyl)-HCID 178418339Butyllithium

Product 1

HCID 27360952,4-Bis(trifluoromethyl)benzaldehyde

Sources & evidence

ORD record
ord-a1ab8ba356b2489299e4f37409546cb0
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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