Hydrochloric Acid → N-[4-Bromo-2-(1-hydroxy-1-thien-2-ylethyl)phenyl]-2-chloroacetamide

HRID 943474Notes

Reaction equation

HRID 943474 reaction equation
[CH2:17]([N:18]([CH2:19][CH3:20])[CH2:21][CH3:22])[CH3:23].[CH2:41]1[O:42][CH2:43][CH2:44][CH2:45]1.[CH3:30][CH2:31][O:32][C:33](=[O:34])[CH3:35].[CH3:36][CH2:37][O:38][CH2:39][CH3:40].[Cl:24][CH2:25][C:26](=[O:27])[Cl:28].[ClH:29].[NH2:1][c:2]1[c:3]([C:9]([CH3:10])([OH:11])[c:12]2[s:13][cH:14][cH:15][cH:16]2)[cH:4][c:5]([Br:8])[cH:6][cH:7]1>>[NH:1]([c:2]1[c:3]([C:9]([CH3:10])([OH:11])[c:12]2[s:13][cH:14][cH:15][cH:16]2)[cH:4][c:5]([Br:8])[cH:6][cH:7]1)[C:26]([CH2:25][Cl:24])=[O:27]

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 6577Chloroacetyl chlorideHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 688643251-(2-Amino-5-bromo-phenyl)-1-thiophen-2-yl-ethanol

Product 1

HCID 68864161N-[4-Bromo-2-(1-hydroxy-1-thien-2-ylethyl)phenyl]-2-chloroacetamide

Sources & evidence

ORD record
ord-0c5fd9c03eea40c6afd36906f863adcf
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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