Chloride → 3-(4-Bromo-2-(2-methyl-2H-[1,2,4]triazol-3-yl)-thiazol-5-yl)-7-(1-ethyl-propyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidine

HRID 943787Notes

Reaction equation

HRID 943787 reaction equation
[Br:12][c:13]1[s:14][c:15](-[c:19]2[c:20]([CH3:34])[n:21][n:22]3[c:23]2[n:24][c:25]([CH3:33])[cH:26][c:27]3[CH:28]([CH2:29][CH3:30])[CH2:31][CH3:32])[c:16]([Br:18])[n:17]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:40][CH2:41][O:42][C:43](=[O:44])[CH3:45].[CH3:6][n:7]1[n:8][cH:9][n:10][cH:11]1.[Cl-:46].[Cl-:48].[Zn+2:47]>>[CH3:6][n:7]1[n:8][cH:9][n:10][c:11]1-[c:13]1[s:14][c:15](-[c:19]2[c:20]([CH3:34])[n:21][n:22]3[c:23]2[n:24][c:25]([CH3:33])[cH:26][c:27]3[CH:28]([CH2:29][CH3:30])[CH2:31][CH3:32])[c:16]([Br:18])[n:17]1

Participants

8

Reactant 7

HCID 312Chloride2×HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 224591H-1,2,4-Triazole, 1-methyl-HCID 32051Zinc(2+)HCID 674295502,4-Dibromo-5-(2,5-dimethyl-7-(pentan-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)thiazoleHCID 178418339Butyllithium

Product 1

HCID 248989763-(4-Bromo-2-(2-methyl-2H-[1,2,4]triazol-3-yl)-thiazol-5-yl)-7-(1-ethyl-propyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidine

Sources & evidence

ORD record
ord-95f4296a4a68411d93dc811a27a7000a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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