Hydrochloric Acid → 2-(3,3-Difluoroazetidin-1-yl)-5-nitropyridine

HRID 947871Notes

Reaction equation

HRID 947871 reaction equation
[CH3:18][CH2:19][N:20]([CH2:21][CH3:22])[CH2:23][CH3:24].[CH3:26][N:27]([CH3:28])[CH:29]=[O:30].[CH3:31][CH2:32][O:33][C:34](=[O:35])[CH3:36].[Cl:8][c:9]1[n:10][cH:11][c:12]([N+:15](=[O:16])[O-:17])[cH:13][cH:14]1.[ClH:1].[F:2][C:3]1([F:7])[CH2:4][NH:5][CH2:6]1.[OH2:25]>>[F:2][C:3]1([F:7])[CH2:4][N:5]([c:9]2[n:10][cH:11][c:12]([N+:15](=[O:16])[O-:17])[cH:13][cH:14]2)[CH2:6]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 962WaterHCID 6228DimethylformamideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 783082-Chloro-5-nitropyridineHCID 27582483,3-Difluoroazetidine

Product 1

HCID 529372622-(3,3-Difluoroazetidin-1-yl)-5-nitropyridine

Sources & evidence

ORD record
ord-3520428410d34e278d0a3a553489995b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…