Propargyl alcohol → 3-(4-(Trifluoromethyl)phenyl)prop-2-yn-1-ol

HRID 952443Notes

Reaction equation

HRID 952443 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([C:8]([F:9])([F:10])[F:11])[cH:6][cH:7]1.[CH2:23]([C:24]#[CH:25])[OH:26].[Cu:32][I:33].[N:12]12[CH2:13][CH2:14][CH2:15][N:16]=[C:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]2.[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1.[Pd:34]([Cl:35])[Cl:36].[c:37]1([P:38]([c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)[c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[cH:51][cH:52][cH:53][cH:54][cH:55]1.[c:56]1([P:57]([c:58]2[cH:59][cH:60][cH:61][cH:62][cH:63]2)[c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)[cH:70][cH:71][cH:72][cH:73][cH:74]1>>[c:2]1([C:25]#[C:24][CH2:23][OH:26])[cH:3][cH:4][c:5]([C:8]([F:9])([F:10])[F:11])[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 7859Propargyl alcoholHCID 8028TetrahydrofuranHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

Product 1

HCID 118304283-(4-(Trifluoromethyl)phenyl)prop-2-yn-1-ol

Sources & evidence

ORD record
ord-37df09818cbd4cb490180977ccd434ae
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…