Cyanide → 5-Chloro-2-cyanopyridine

HRID 955077Notes

Reaction equation

HRID 955077 reaction equation
[C-:23]#[N:24].[C-:26]#[N:27].[CH3:12][N:13]([CH3:14])[CH:15]=[O:16].[CH3:17][CH2:18][O:19][C:20](=[O:21])[CH3:22].[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:8])[cH:6][cH:7]1.[Cl:29][Pd:30][Cl:31].[Cl:9][CH2:10][Cl:11].[Zn+2:25].[Zn:28]>>[c:2]1([C:12]#[N:13])[n:3][cH:4][c:5]([Cl:8])[cH:6][cH:7]1

Participants

9

Reactant 8

HCID 5975Cyanide2×HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 23994ZincHCID 24290Palladium ChlorideHCID 276852,5-DichloropyridineHCID 32051Zinc(2+)

Product 1

HCID 38339425-Chloro-2-cyanopyridine

Sources & evidence

ORD record
ord-417ccd1a12ee402d904d2924cdde631f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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