Ammonium → Tert-butyl 4-(2-ethoxy-2-oxoethyl)-4-hydroxypiperidine-1-carboxylate

HRID 955694Notes

Reaction equation

HRID 955694 reaction equation
[C:15]([CH3:16])([CH3:17])([CH3:18])[O:19][C:20](=[O:21])[N:22]1[CH2:23][CH2:24][C:25](=[O:28])[CH2:26][CH2:27]1.[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:2][CH:3]([N-:4][CH:5]([CH3:6])[CH3:7])[CH3:8].[CH3:9][CH2:10][O:11][C:12]([CH3:13])=[O:14].[Cl-:29].[Li+:1].[NH4+:30]>>[CH3:9][CH2:10][O:11][C:12]([CH2:13][C:25]1([OH:28])[CH2:24][CH2:23][N:22]([C:20]([O:19][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:21])[CH2:27][CH2:26]1)=[O:14]

Participants

8

Reactant 7

HCID 223AmmoniumHCID 312ChlorideHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 28486Lithium ionHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 5062348Diisopropylamide

Product 1

HCID 10469302Tert-butyl 4-(2-ethoxy-2-oxoethyl)-4-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-44cbd4773372480088b792966e43afee
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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