2-Methyl-3-butyn-2-ol → 4-(4-Cyanophenyl)-2-methyl-3-butyne-2-ol

HRID 956008Notes

Reaction equation

HRID 956008 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([C:6]#[N:7])[cH:8][cH:9]1.[CH3:10][C:11]([C:12]#[CH:13])([CH3:14])[OH:15].[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[Cu:42][I:43].[c:16]1([P:17]([c:18]2[cH:19][cH:20][cH:21][cH:22][cH:23]2)[c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[cH:30][cH:31][cH:32][cH:33][cH:34]1>>[c:2]1([C:13]#[C:12][C:11]([CH3:10])([CH3:14])[OH:15])[cH:3][cH:4][c:5]([C:6]#[N:7])[cH:8][cH:9]1

Participants

6

Reactant 5

HCID 82582-Methyl-3-butyn-2-olHCID 8471TriethylamineHCID 11776TriphenylphosphineHCID 12162Benzonitrile, 4-bromo-HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

Product 1

HCID 28221554-(4-Cyanophenyl)-2-methyl-3-butyne-2-ol

Sources & evidence

ORD record
ord-38977bc3454e4c81ac1198eb55eae590
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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