Triethylamine → 3-Bromo-5-(3-trifluoromethylphenylethynyl)-pyridine

HRID 956174Notes

Reaction equation

HRID 956174 reaction equation
[Br:8][c:9]1[cH:10][n:11][cH:12][c:13]([C:15]#[CH:16])[cH:14]1.[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[CH3:28][CH2:29][O:30][C:31](=[O:32])[CH3:33].[Cu:34][I:35].[I:17][c:18]1[cH:19][c:20]([C:24]([F:25])([F:26])[F:27])[cH:21][cH:22][cH:23]1.[Pd:36]([Cl:37])[Cl:38].[c:39]1([P:40]([c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)[cH:53][cH:54][cH:55][cH:56][cH:57]1.[c:58]1([P:59]([c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[cH:72][cH:73][cH:74][cH:75][cH:76]1>>[Br:8][c:9]1[cH:10][n:11][cH:12][c:13]([C:15]#[C:16][c:18]2[cH:19][c:20]([C:24]([F:25])([F:26])[F:27])[cH:21][cH:22][cH:23]2)[cH:14]1

Participants

8

Reactant 7

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 67868Benzene, 1-iodo-3-(trifluoromethyl)-HCID 154238793-Bromo-5-ethynylpyridine

Product 1

HCID 665244133-Bromo-5-(3-trifluoromethylphenylethynyl)-pyridine

Sources & evidence

ORD record
ord-5e8d26fad2564bfab422f42d5a849437
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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