1,2-Dichloroethane → Tert-butyl 2-[[5-[(4-bromophenyl)methyl]-7-(3,5-dichlorophenyl)-5-methyl-6-oxoimidazo[1,2-a]imidazole-3-carbonyl]amino]propanoate

HRID 958476Notes

Reaction equation

HRID 958476 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][C:7]2([CH3:27])[C:8](=[O:26])[N:9]([c:18]3[cH:19][c:20]([Cl:25])[cH:21][c:22]([Cl:24])[cH:23]3)[c:10]3[n:11]2[c:12]([C:15](=[O:16])[OH:17])[cH:13][n:14]3)[cH:28][cH:29]1.[C:31]([CH3:32])([CH3:33])([CH3:34])[O:35][C:36]([CH:37]([CH3:38])[NH2:39])=[O:40].[CH2:51]([Cl:52])[CH2:53][Cl:54].[CH3:60][N:61]([c:62]1[cH:63][cH:64][n:65][cH:66][cH:67]1)[CH3:68].[ClH:30].[O:55]=[CH:56][N:57]([CH3:58])[CH3:59].[OH2:69].[OH:41][n:42]1[c:43]2[c:44]([cH:45][cH:46][cH:47][cH:48]2)[n:49][n:50]1>>[Br:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][C:7]2([CH3:27])[C:8](=[O:26])[N:9]([c:18]3[cH:19][c:20]([Cl:25])[cH:21][c:22]([Cl:24])[cH:23]3)[c:10]3[n:11]2[c:12]([C:15](=[O:17])[NH:39][CH:37]([C:36]([O:35][C:31]([CH3:32])([CH3:33])[CH3:34])=[O:40])[CH3:38])[cH:13][n:14]3)[cH:28][cH:29]1

Participants

9

Reactant 8

HCID 111,2-DichloroethaneHCID 313Hydrochloric AcidHCID 962WaterHCID 6228DimethylformamideHCID 142844-(Dimethylamino)pyridineHCID 757711-HydroxybenzotriazoleHCID 4351123Tert-butyl 2-aminopropanoateHCID 18338046HCID 18338046, compound

Product 1

HCID 67389776Tert-butyl 2-[[5-[(4-bromophenyl)methyl]-7-(3,5-dichlorophenyl)-5-methyl-6-oxoimidazo[1,2-a]imidazole-3-carbonyl]amino]propanoate

Sources & evidence

ORD record
ord-9df0853816314de5a027e26d48042f83
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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