Acetate → 6-Methyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid ethyl ester
Reaction equation
[Br:14][c:15]1[cH:16][n:17][cH:18][n:19][cH:20]1.[C:21](=[O:22])([O-:23])[O-:24].[C:87]([O:88][CH2:89][CH3:90])(=[O:91])[CH3:92].[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[n:7][c:8]([CH3:13])[cH:9][n:10][c:11]1[NH2:12].[CH3:93][CH2:94][CH2:95][CH2:96][CH2:97][CH2:98][CH3:99].[K+:25].[K+:26].[O-:79][C:80]([CH3:81])=[O:82].[O-:83][C:84]([CH3:85])=[O:86].[OH2:77].[Pd+2:78].[c:27]1([P:28]([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[c:35]2[c:36]3[c:60]([cH:61][cH:62][cH:63]2)[C:57]([CH3:58])([CH3:59])[c:39]2[c:38]([c:43]([P:44]([c:45]4[cH:46][cH:47][cH:48][cH:49][cH:50]4)[c:51]4[cH:52][cH:53][cH:54][cH:55][cH:56]4)[cH:42][cH:41][cH:40]2)[O:37]3)[cH:64][cH:65][cH:66][cH:67][cH:68]1.[c:69]1([CH3:70])[c:71]([CH3:72])[cH:73][cH:74][cH:75][cH:76]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[n:7][c:8]([CH3:13])[cH:9][n:10][c:11]1[NH:12][c:15]1[cH:16][n:17][cH:18][n:19][cH:20]1Participants
12
Reactant 11
HCID 175Acetate2×
HCID 813Potassium Cation2×
HCID 962Water
HCID 7237O-Xylene
HCID 8857Ethyl Acetate
HCID 8900Heptane
HCID 19660Carbonate Ion
HCID 783445-Bromopyrimidine
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 317738Ethyl 3-amino-6-methylpyrazine-2-carboxylate
HCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)Product 1
Sources & evidence
- ORD record
- ord-f4e446bc24b74e8f8bb4b50616c04e50
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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