Benzene → 2H-1-Benzothiopyran-4-carbonitrile

HRID 961688Notes

Reaction equation

HRID 961688 reaction equation
[CH3:12][Si:13]([CH3:14])([CH3:15])[C:16]#[N:17].[Cl:33][CH2:34][Cl:35].[ClH:23].[I-:30].[I-:32].[P:18]([Cl:19])([Cl:20])([Cl:21])=[O:22].[S:1]1[CH2:2][CH2:3][C:4](=[O:11])[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21.[Zn+2:31].[cH:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1.[cH:36]1[cH:37][cH:38][n:39][cH:40][cH:41]1>>[S:1]1[CH2:2][CH:3]=[C:4]([C:16]#[N:17])[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21

Participants

10

Reactant 9

HCID 241BenzeneHCID 313Hydrochloric AcidHCID 1049PyridineHCID 6344DichloromethaneHCID 19048Thiochroman-4-oneHCID 24813Phosphorus oxychlorideHCID 30165Iodide Ion2×HCID 32051Zinc(2+)HCID 82115Trimethylsilyl cyanide

Product 1

HCID 132277052H-1-Benzothiopyran-4-carbonitrile

Sources & evidence

ORD record
ord-4a1680fad53740ddbd7aee825dfd0611
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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