反应详情

3-(4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepin-6-yl)propionic acid (13.5 g) was dissolved in dimethylformamide (140 ml). Potassium carbonate (9.1 g) and iodoethane (2.9 ml) were added, and the mixture was stirred for 4 hours. Ethyl acetate and water were added thereto. The organic layer was taken out, washed with brine and dried over magnesium sulfate. The solvent was evaporated, and the residue was crystallized from diisopropyl ether to give 11.2 g of ethyl 3-(4-(2-chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepin-6-yl)propionate.

1. washwashed with brine
2. dry with materialdried over magnesium sulfate
3. customThe solvent was evaporated
4. customthe residue was crystallized from diisopropyl ether