Iodine → HCID 23295948, compound

This example illustrates a synthesis for inventive compound no. 351 3. To a suspension of magnesium (1.86 g, 77.2 mmol) and a crystal of iodine in THF (20 ml) was added 10-undecenyl bromide (6.00 g, 25.8 mmol) in THF (14 m) over 40 minutes and the reaction stirred for a further 30 minutes after completion of the addition. The solution was added via a canula over 50 minutes to a suspension of copper iodide (0.50 g, 2.58 mmol) and 1-bromo-3-chloropropane (3.84 ml, 38.7 mmol) in THF (20 ml) and stirred at 25° C. for 16 hours. Sulfuric acid (1.0 M, 50 ml) was added, extracted with diethyl ether (2×60 ml) and the organic solvent was dried over magnesium sulfate and subsequently evaporated The residue was distilled at 0.25 mmHg, producing 3.06 g of 13-tetradecenyl chloride as a colorless liquid (51% yield, b.p. 98°-100° C.).

1. customa synthesis for inventive compound no
2. additionafter completion of the addition
3. stirringstirred at 25° C. for 16 hours
4. extractionextracted with diethyl ether (2×60 ml)
5. dry with materialthe organic solvent was dried over magnesium sulfate
6. customsubsequently evaporated The residue
7. distillationwas distilled at 0.25 mmHg

ORD record

ord-f7432a83db764a4b9f959194dcf3dbd0

Source dataset

uspto-grants-1998_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05770595