Nitrogen → N,N'-Dicyclohexylurea

HRID 968458Notes

Reaction equation

HRID 968458 reaction equation
[CH:1]1([N:7]=[C:8]=[N:9][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.N#N.C1C[O:28]CC1>>[CH:10]1([NH:9][C:8]([NH:7][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)=[O:28])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

5

Reactant 4

HCID 947NitrogenHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 10868Dicyclohexylcarbodiimide

Product 1

HCID 4277N,N'-Dicyclohexylurea

Procedure

By mixing 0.1 g of polymer coupling agent from step 2, 0.15 g of 1,3-dicyclohexylcarbodiimide (DCC) in 2 g of THF, a 5 wt % polymer coupling agent solution is prepared. 20 μL of triethylamine is added into the mixture. The solution is then pumped into the capillary by N2 pressure. After 3 drops of the initiator solution come out of the other end of the capillary, both ends of the capillary are sealed with a silicon rubber septum. The reaction is allowed to proceed for 12.0 hour at room temperature. The capillary is then rinsed with acetone for 1.0 hour.

Workup

  1. customis prepared
  2. customboth ends of the capillary are sealed with a silicon rubber septum
  3. washThe capillary is then rinsed with acetone for 1.0 hour

Sources & evidence

ORD record
ord-81db4254293241c8af6d963c815f8def
Source dataset
uspto-grants-2007_12
Patent number
US07303821B1

Reaction notes

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