Water → HCID 86590095, compound

HRID 968460Notes

Reaction equation

HRID 968460 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[S:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1.O.C([O:19]CC)C>[N+](C)([O-])=O>[Br-:1].[O:19]=[C:12]1[CH2:13][CH2:14][CH2:15][S+:11]1[CH2:2][CH2:3][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

6

Reactant 4

HCID 962WaterHCID 1127TetrahydrothiopheneHCID 3283Diethyl EtherHCID 6259Phenacyl bromide

Product 1

HCID 86590095HCID 86590095, compound

Reagents, catalysts & solvents 1

HCID 6375NitromethaneSolvent

Procedure

The 2-bromoacetophenone of 4.97 g (0.025 moles) was dissolved in nitromethane of 9.5 g. Tetrahydrothiophene of 2.2 g (0.025 moles) was added at room temperature, and was matured as it is for two hours at room temperature. A reaction liquid was hardened by the progression of reactions. Solids were dissolved by adding 70 g of water and 50 g of diethyl ether. A water layer was separated and washed with 50 g of diethyl ether of 50 g so that lipophilic impurities were removed.

Workup

  1. customA reaction liquid
  2. dissolutionSolids were dissolved
  3. customA water layer was separated
  4. washwashed with 50 g of diethyl ether of 50 g so that lipophilic impurities
  5. customwere removed

Sources & evidence

ORD record
ord-333a045f3093434c9040e5bd17b76989
Source dataset
uspto-grants-2007_12
Patent number
US07303852B2

Reaction notes

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