Sodium Iodide → HCID 68908797, compound

HRID 969434Notes

Reaction equation

[CH2:1]([CH:6]1[CH2:12][CH:11]2[NH:13][CH:8]([CH2:9][CH2:10]2)[CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5].[Na+].[I-].C([O-])([O-])=O.[K+].[K+].[CH3:22][N:23]([CH:25]=[O:26])[CH3:24]>>[CH3:8][C@H:9]([CH2:10][N:13]1[CH:11]2[CH2:10][CH2:9][C@H:8]1[CH2:7][CH:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[CH2:12]2)[CH2:22][N:23]1[C:24]2[C:3](=[CH:2][CH:1]=[CH:6][CH:7]=2)[CH2:4][CH2:5][C:25]1=[O:26]

Participants

Reactant 4

HCID 5238Sodium Iodide

HCID 6228Dimethylformamide

HCID 11430Potassium Carbonate

HCID 219898523-Pentyl-8-azabicyclo[3.2.1]octane

Product 1

HCID 68908797HCID 68908797, compound

Procedure

Crude (R,S)-1-(3-chloro-2-methylpropyl)-3,4-dihydro-1H-quinolin-2-one (107LH63)(0.094 g), 3-pentyl-8-azabicyclo[3.2.1]octane (0.027 g, 0.15 mmol), NaI (0.100 g, 0.67 mmol), and K2CO3 (0.075 g, 0.54 mmol) in DMF (1 mL) were reacted and purified according to GP20 to give the title compound (107LH74-c5)(0.025 g). HPLC-MS (ammonium acetate) [M+H]+=383.34

Workup

custompurified

Sources & evidence

ORD record: ord-e55c3ebaf5214187804852dcf365d2c4
Source dataset: uspto-grants-2007_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07307075B2

Reaction notes

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