Hydrochloric Acid → Ethyl 4-(4-methoxyphenyl)phenylacetate

A solution of 2.6 g (4.0 mmol) of dichlorobis(triphenylphosphine) nickel and 2.1 g (8.0 mmol) of triphenylphosphine in 30 ml of ether was cooled to 0° C. in an argon atmosphere. To this solution, 1.8 M ethylmagnesium bromide solution in ether was added in an amount of 4.4 ml (8.0 mmol). The resulting mixture was stirred for 1 hour, and the solvent was then removed by evaporation under reduced pressure. To the residue was added a solution of 4.3 g (16.4 mmol) of 4-bromo-4'-methoxybiphenyl in 20 ml of tetrahydrofuran (THF) and 30 ml of dimethoxymethane, and was also added 10 ml of hexamethylphosphoric triamide (HMPA). Thereto was added at 0° C. a Reformatsky reagent prepared from 10.0 g (60.0 mmol) of ethyl bromoacetate, 6.5 g (100 mmol) of zinc, and 10 ml of dimethoxymethane. The resulting mixture was stirred at room temperature overnight. Thereafter, 50 ml of 3 M hydrochloric acid was added thereto, and this mixture was subjected to extraction with 250 ml of ether. The resulting ether solution was washed with purified water, and then concentrated under reduced pressure. The residue was separated and purified by column chromatography (hexane/ethyl acetate=5/1), thereby obtaining 2.16 g (yield 51%) of ethyl 4-(4-methoxyphenyl)phenylacetate.

1. customthe solvent was then removed by evaporation under reduced pressure
2. additionThereto was added at 0° C. a Reformatsky reagent
3. stirringThe resulting mixture was stirred at room temperature overnight
4. extractionthis mixture was subjected to extraction with 250 ml of ether
5. washThe resulting ether solution was washed with purified water
6. concentrationconcentrated under reduced pressure
7. customThe residue was separated
8. custompurified by column chromatography (hexane/ethyl acetate=5/1)

ORD record

ord-b592498e25e940fb9bc061efe80c9d5e

Source dataset

uspto-grants-1991_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05064564