Diisopropyl Ether → HCID 54240092, compound

HRID 974335Notes

Reaction equation

HRID 974335 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][NH:7][CH2:8][CH2:9][C:10]=2[N:11]=1.C(=O)([O-])[O-].[K+].[K+].[Br:18][C:19]1[CH:28]=[CH:27][CH:26]=[CH:25][C:20]=1[CH:21]=[CH:22][CH2:23]Br.C(OC(C)C)(C)C>CN(C)C=O>[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:23][CH:22]=[CH:21][C:20]3[CH:25]=[CH:26][CH:27]=[CH:28][C:19]=3[Br:18])[CH2:8][CH2:9][C:10]=2[N:11]=1

Participants

6

Reactant 4

HCID 7914Diisopropyl EtherHCID 11430Potassium CarbonateHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 536882711-Bromo-2-(3-bromo-1-propen-1-yl)benzene

Product 1

HCID 54240092HCID 54240092, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Example 1 from 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine, potassium carbonate and 2-bromo-cinnamyl bromide in anhydrous dimethylformamide for 2 hours at 20° C. Yield: 42% of theory, Melting point: 103°-106° C. (diisopropylether).

Sources & evidence

ORD record
ord-ea78143dc56d4c898a458d47f0192369
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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