反应详情

A solution of 4-octyloxyphenylglyoxylic acid (0.935 g) in a mixture of water (9 ml) and tetrahydrofuran (18 ml) was adjusted to pH 3.5-4 with 1N hydrochloric acid, and methoxyamine hydrochloride (0.337 g) was added thereto at room temperature. The mixture was stirred for 2 hours at room temperature maintaining pH 3.5-4 with 1N hydrochloric acid. The reaction mixture was added to ethyl acetate. The organic layer was separated and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 2-(4-octyloxyphenyl)-2-methoxyiminoacetic acid (0.57 g).

1. additionwas added
2. customat room temperature
3. customThe organic layer was separated
4. dry with materialdried over magnesium sulfate
5. filtrationThe magnesium sulfate was filtered off
6. customthe filtrate was evaporated under reduced pressure