Sodium Iodide → HCID 19955567, compound

HRID 976440Notes

Reaction equation

HRID 976440 reaction equation
[C:1]1([CH2:7][O:8][N:9]=[C:10]2[CH2:24][CH:13]3[CH2:14][N:15]([C:17](OC(C)(C)C)=[O:18])[CH2:16][CH:12]3[CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.F[C:26](F)(F)C(O)=O.ClCC(OC(=O)CCl)=O.[Na+].[I-:42]>C(Cl)Cl.CC(C)=O.C(N(CC)CC)C>[I:42][CH2:26][C:17]([N:15]1[CH2:16][CH:12]2[CH2:11][C:10](=[N:9][O:8][CH2:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:24][CH:13]2[CH2:14]1)=[O:18]

Participants

8

Reactant 4

HCID 5238Sodium IodideHCID 6422Trifluoroacetic acidHCID 10946Chloroacetic anhydrideHCID 19967241HCID 19967241, compound

Product 1

HCID 19955567HCID 19955567, compound

Reagents, catalysts & solvents 3

HCID 180AcetoneSolventHCID 6344DichloromethaneSolventHCID 8471TriethylamineSolvent

Procedure

The title compound of example F is treated with trifluoroacetic acid in methylene chloride at room temperature. The volatiles are removed under reduced pressure to afford a residue which is treated with chloroacetic anhydride and triethylamine. The chloroacetylated material is then reacted with NaI in acetone to give the title compound.

Workup

  1. customThe volatiles are removed under reduced pressure
  2. customto afford a residue which

Sources & evidence

ORD record
ord-ea9cb383a9694305a781a2c308e30aed
Source dataset
uspto-grants-1997_03
Patent number
US05612366

Reaction notes

Loading…