Water → HCID 12822509, compound

HRID 980292Notes

Reaction equation

HRID 980292 reaction equation
Cl[C:2]([O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:3].[CH3:12][NH:13][CH2:14][CH2:15][C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([CH2:25][NH:26][S:27]([CH3:30])(=[O:29])=[O:28])[CH:23]=2)[NH:18][CH:17]=1.C(N(C(C)C)CC)(C)C.O>C1COCC1>[C:6]1([CH2:5][O:4][C:2](=[O:3])[N:13]([CH2:14][CH2:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([CH2:25][NH:26][S:27]([CH3:30])(=[O:29])=[O:28])[CH:23]=3)[NH:18][CH:17]=2)[CH3:12])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

6

Reactant 4

HCID 962WaterHCID 10387Benzyl chloroformateHCID 81531DiisopropylethylamineHCID 12822473HCID 12822473, compound

Product 1

HCID 12822509HCID 12822509, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Benzyl chloroformate (1.1 ml) was added to a stirred, ice-cooled solution of N-[[3-[2-(methylamino)ethyl]-1H-indol-5-yl]methyl]methanesulphonamide (1.3 g) and diisopropylethylamine (1.5 ml) in dry THF (40 ml). After 1/2 h, water (3 ml) was added and the stirring was continued for 1 h.

Workup

  1. waitthe stirring was continued for 1 h.

Sources & evidence

ORD record
ord-a52043632f24451fb5ad00d6d75ce6cf
Source dataset
uspto-grants-1987_01
Patent number
US04636521

Reaction notes

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