HRID983173

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11

1,2-Dichloroethane

C2H4Cl2

HCID33944

N-(2-Aminoethyl)piperidine

C7H16N2

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

$结构：Cc1cc(C(=O)O)c(/C=C2\C(=O)Nc3cccc(-c4cccc(F)c4)c32)[nH]1$

HCID69740587

未命名化合物

PRODUCTS

生成物

$结构：Cc1cc(C(=O)NCCN2CCCCC2)c(/C=C2\C(=O)Nc3cccc(-c4cccc(F)c4)c32)[nH]1$

HCID60061591

未命名化合物

收率 70%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

2-[4-(3-Fluoro-phenyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-5-methyl-1H-pyrrole-3-carboxylic acid (90.5 mg) was coupled with 2-piperidin-1-yl-ethylamine (48 mg, 1.5 eq.), HOBt (1 eq.), EDC (1.5 eq.) and TEA (3 drops) in THF (2 mL), DMF (0.3 mL) at rt for overnight to give 82 mg (70%) of the titled compound as a yellow solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4f84cf8c844a47eba0c4d92919065ce1
来源数据集: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06861418B2
来源说明: uspto-grants-2005_03

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:16]=[CH:15][CH:14]=[C:13]3[C:9]=2/[C:10](=[CH:18]/[C:19]2[NH:20][C:21]([CH3:27])=[CH:22][C:23]=2[C:24](O)=[O:25])/[C:11](=[O:17])[NH:12]3)[CH:5]=[CH:6][CH:7]=1.[N:28]1([CH2:34][CH2:35][NH2:36])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1.C1C=CC2N(O)N=NC=2C=1.C(Cl)CCl>C1COCC1.CN(C=O)C>[N:28]1([CH2:34][CH2:35][NH:36][C:24]([C:23]2[CH:22]=[C:21]([CH3:27])[NH:20][C:19]=2/[CH:18]=[C:10]2\[C:11](=[O:17])[NH:12][C:13]3[C:9]\2=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=2)[CH:16]=[CH:15][CH:14]=3)=[O:25])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1