Hydrochloric Acid → tert-butyl N-methyl-N-[1-[methyl(2-thiophen-2-ylethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]carbamate

HRID 100286Notes

Reaction equation

HRID 100286 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH3:9])[CH:10]([C:11](=[O:12])[OH:13])[CH2:14][c:15]1[cH:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]2[cH:23][cH:24]1.[CH2:56]([N:57]([CH:58]([CH3:59])[CH3:60])[CH:61]([CH3:62])[CH3:63])[CH3:64].[CH3:36][N:37]([CH3:38])[CH2:39][CH2:40][CH2:41][N:42]=[C:43]=[N:44][CH2:45][CH3:46].[CH3:47][NH:48][CH2:49][CH2:50][c:51]1[s:52][cH:53][cH:54][cH:55]1.[CH3:65][N:66]([CH3:67])[CH:68]=[O:69].[CH3:73][CH2:74][O:75][C:76](=[O:77])[CH3:78].[Cl:70][CH2:71][Cl:72].[ClH:35].[OH:25][n:26]1[c:27]2[n:28][cH:29][cH:30][cH:31][c:32]2[n:33][n:34]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH3:9])[CH:10]([C:11](=[O:13])[N:48]([CH3:47])[CH2:49][CH2:50][c:51]1[s:52][cH:53][cH:54][cH:55]1)[CH2:14][c:15]1[cH:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]2[cH:23][cH:24]1

Participants

10

Reactant 9

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 81531DiisopropylethylamineHCID 181649HOAtHCID 436154N-Methyl-2-(thiophen-2-yl)ethan-1-amineHCID 223269722-[Methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]-3-naphthalen-2-ylpropanoic acid

Product 1

HCID 20677531tert-butyl N-methyl-N-[1-[methyl(2-thiophen-2-ylethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]carbamate

Sources & evidence

ORD record
ord-d68f570cf86e440c9d9ec6f9c6b090ae
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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