Hydrochloric Acid → N-{2-fluoro-5-[(2-{[(2-methylcyclopropyl)carbonyl]amino}imidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide

HRID 1214770

Reaction equation

HRID 1214770 reaction equation
[CH3:1][CH:2]1[CH:3]([C:5](=[O:6])[OH:7])[CH2:4]1.[CH3:48][N:49]([CH3:50])[C:51](=[O:52])[CH3:53].[CH3:8][N:9]([CH3:10])[CH:11]=[O:12].[Cl:13][C:14]([C:15]([Cl:16])=[O:17])=[O:18].[ClH:19].[NH2:20][c:21]1[n:22][c:23]2[n:24]([n:25][c:26]([O:29][c:30]3[cH:31][cH:32][c:33]([F:46])[c:34]([NH:36][C:37](=[O:38])[c:39]4[cH:40][c:41]([CH3:45])[n:42][n:43]4[CH3:44])[cH:35]3)[cH:27][cH:28]2)[cH:47]1.[O:54]1[CH2:55][CH2:56][CH2:57][CH2:58]1>>[CH3:1][CH:2]1[CH:3]([C:5](=[O:7])[NH:20][c:21]2[n:22][c:23]3[n:24]([n:25][c:26]([O:29][c:30]4[cH:31][cH:32][c:33]([F:46])[c:34]([NH:36][C:37](=[O:38])[c:39]5[cH:40][c:41]([CH3:45])[n:42][n:43]5[CH3:44])[cH:35]4)[cH:27][cH:28]3)[cH:47]2)[CH2:4]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 31374DimethylacetamideHCID 65578Oxalyl chlorideHCID 998732-Methylcyclopropanecarboxylic acidHCID 57505568N-[5-(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy-2-fluorophenyl]-2,5-dimethylpyrazole-3-carboxamide

Product 1

HCID 57505604N-{2-fluoro-5-[(2-{[(2-methylcyclopropyl)carbonyl]amino}imidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide

Sources & evidence

ORD record
ord-d385d07a38b54ca9b4dca8109dab4da7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Linked notes

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