Oxalyl chloride → HCID 22262307, compound

HRID 1610206Notes

Reaction equation

HRID 1610206 reaction equation
[O:1]=[C:2]1[C:14]2[CH:13]=[CH:12][CH:11]=[C:10]([C:15](O)=[O:16])[C:9]=2[C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2.C(Cl)(=O)C(Cl)=O.Cl.[F:25][C:26]1[CH:31]=[CH:30][C:29]([CH:32]([OH:46])[CH:33]([NH2:45])[CH2:34][C:35]2[CH:40]=[CH:39][C:38]([C:41]([F:44])([F:43])[F:42])=[CH:37][CH:36]=2)=[CH:28][CH:27]=1.C(=O)([O-])O.[Na+]>O1CCCC1.C(OCC)(=O)C.O.CN(C)C=O>[F:25][C:26]1[CH:27]=[CH:28][C:29]([CH:32]([OH:46])[CH:33]([NH:45][C:15]([C:10]2[C:9]3[C:8]4[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=4)[C:2](=[O:1])[C:14]=3[CH:13]=[CH:12][CH:11]=2)=[O:16])[CH2:34][C:35]2[CH:40]=[CH:39][C:38]([C:41]([F:44])([F:43])[F:42])=[CH:37][CH:36]=2)=[CH:30][CH:31]=1

Participants

9

Reactant 4

HCID 65578Oxalyl chlorideHCID 803619-Oxofluorene-4-carboxylic acidHCID 516892Sodium BicarbonateHCID 22261728(1RS,2RS)-1-(4-fluorophenyl)-1-hydroxy-3-(4-(trifluoromethyl)phenyl)-2-propylamine hydrochloride

Product 1

HCID 22262307HCID 22262307, compoundYield 69%

Reagents, catalysts & solvents 4

HCID 962WaterSolventHCID 6228DimethylformamideSolventHCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 9-oxo-9H-fluorene-4-carboxylic acid (144 mg, 0.64 mmol) in tetrahydrofuran (5 ml) were added oxalyl chloride (0.11 ml, 1.72 mmol) and N,N-dimethylformamide (0.01 ml), and the mixture was stirred at room temperature for 30 min. The reaction solution was evaporated under reduced pressure. To a solution of the residue in ethyl acetate (5 ml) were added (1RS,2SR)-1-(4-fluorophenyl)-1-hydroxy-3-(4-(trifluoromethyl)phenyl)-2-propylamine hydrochloride (150 mg, 0.43 mmol) and saturated aqueous sodium hydrogen carbonate (5 ml) and the mixture was stirred overnight at room temperature. The reaction solution was diluted with water (50 ml), and extracted with ethyl acetate (50 ml×2). The extract was washed with saturated brine, dried over anhydrous magnesium sulfate and evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1-1:1) and recrystallized from ethyl acetate-hexane to give the title compound (154 mg, 69%).

Workup

  1. customThe reaction solution was evaporated under reduced pressure
  2. stirringthe mixture was stirred overnight at room temperature
  3. extractionextracted with ethyl acetate (50 ml×2)
  4. washThe extract was washed with saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customevaporated under reduced pressure
  7. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1-1:1)
  8. customrecrystallized from ethyl acetate-hexane

Sources & evidence

ORD record
ord-079e71afb1b941a8ab13cd7703dd703c
Source dataset
uspto-grants-2006_01
Patent number
US06982348B2

Reaction notes

Loading…