Hydrochloric Acid → 6-[2-[3-(difluoromethoxy)-2-(2,2-dimethylpropoxy)phenyl]ethenyl]-N-[[3-(trifluoromethyl)phenyl]methyl]imidazo[2,1-b][1,3]thiazole-5-carboxamide

HRID 94337

Reaction equation

HRID 94337 reaction equation
[CH2:63]1[O:64][CH2:65][CH2:66][CH2:67]1.[CH3:42][CH2:43][N:44]=[C:45]=[N:46][CH2:47][CH2:48][CH2:49][N:50]([CH3:51])[CH3:52].[CH3:54][N:55]([c:56]1[cH:57][cH:58][n:59][cH:60][cH:61]1)[CH3:62].[ClH:53].[F:1][CH:2]([O:3][c:4]1[c:5]([O:23][CH2:24][C:25]([CH3:26])([CH3:27])[CH3:28])[c:6]([CH:10]=[CH:11][c:12]2[n:13][c:14]3[s:15][cH:16][cH:17][n:18]3[c:19]2[C:20](=[O:21])[OH:22])[cH:7][cH:8][cH:9]1)[F:29].[F:30][C:31]([c:32]1[cH:33][c:34]([CH2:38][NH2:39])[cH:35][cH:36][cH:37]1)([F:40])[F:41].[O:68]=[CH:69][N:70]([CH3:71])[CH3:72]>>[F:1][CH:2]([O:3][c:4]1[c:5]([O:23][CH2:24][C:25]([CH3:26])([CH3:27])[CH3:28])[c:6]([CH:10]=[CH:11][c:12]2[n:13][c:14]3[s:15][cH:16][cH:17][n:18]3[c:19]2[C:20](=[O:21])[NH:39][CH2:38][c:34]2[cH:33][c:32]([C:31]([F:30])([F:40])[F:41])[cH:37][cH:36][cH:35]2)[cH:7][cH:8][cH:9]1)[F:29]

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 142844-(Dimethylamino)pyridineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 759623-(Trifluoromethyl)benzylamineHCID 684073476-[2-[3-(Difluoromethoxy)-2-(2,2-dimethylpropoxy)phenyl]ethenyl]imidazo[2,1-b][1,3]thiazole-5-carboxylic acid

Product 1

HCID 673817446-[2-[3-(difluoromethoxy)-2-(2,2-dimethylpropoxy)phenyl]ethenyl]-N-[[3-(trifluoromethyl)phenyl]methyl]imidazo[2,1-b][1,3]thiazole-5-carboxamide

Sources & evidence

ORD record
ord-12345f8163f74861b7194c4770521fe2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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