反応式
C1(C(C2C=CC=CC=2)C2CCNCC2)C=CC=CC=1.[N+](C1C=CC(CCl)=CC=1)([O-])=O.C(=O)([O-])[O-].[Na+].[Na+].[N+:37]([C:40]1[CH:45]=[CH:44][C:43]([CH2:46][N:47]2[CH2:52][CH2:51][CH:50]([CH:53]([C:60]3[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=3)[C:54]3[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=3)[CH2:49][CH2:48]2)=[CH:42][CH:41]=1)([O-])=O.[H][H]>C(O)C.O.O1CCCC1.[Pd]>[C:60]1([CH:53]([C:54]2[CH:55]=[CH:56][CH:57]=[CH:58][CH:59]=2)[CH:50]2[CH2:49][CH2:48][N:47]([CH2:46][C:43]3[CH:42]=[CH:41][C:40]([NH2:37])=[CH:45][CH:44]=3)[CH2:52][CH2:51]2)[CH:61]=[CH:62][CH:63]=[CH:64][CH:65]=1参加物
反応物 5
生成物 1
試薬・触媒・溶媒 4
実験手順
The basic primary amine of this invention can be prepared by heating 4-(diphenylmethyl)piperidine with 4-nitrobenzyl chloride in the presence of sodium carbonate, using ethanol and water as solvents, and contacting the resultant 1-[(4-nitrophenyl)methyl]-4-(diphenylmethyl)piperidine in tetrahydrofuran solution at 25° with hydrogen under approximately 0.1 atm of pressure, using 5% palladium-on-charcoal as catalyst. From 4-{[4-(diphenylmethyl)-1-piperidinyl]methyl}benzenamine thus or otherwise produced, on heating in acetic acid solution with an alkanoic acid anhydride, a corresponding basic N-alkanoyl amine of this invention can be prepared. And by heating a dichloromethane solution of 4-(diphenylmethyl)piperidine and 4-[(alkylamino)/(dialkylamino)]benzoic acid in the presence of N,N1 -methanetetraylbiscyclohexanamine, then heating the resultant amide with lithium tetrahydroaluminate(1-) in tetrahydrofuran, a corresponding basic N-alkyl or N,N-dialkyl amine of this invention can be prepared.
後処理
- customat 25°
出典と根拠
- ORDレコード
- ord-07f3a93d72e64b0d82d8deca20c384b3
- 出典データセット
- uspto-grants-1977_07
- 特許番号
- US04035372
関連ノート
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