Anthranilic Acid → 2-(Octanoylamino)benzoic acid

HRID 36312

反応式

HRID 36312 の反応式
[C:1]([OH:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].N1C=[CH:15][CH:14]=[CH:13][CH:12]=1.[Cl-].Cl.[O:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>>[C:20]([NH:4][C:3]1[C:2](=[CH:8][CH:7]=[CH:6][CH:5]=1)[C:1]([OH:10])=[O:9])(=[O:19])[CH2:21][CH2:22][CH2:23][CH2:12][CH2:13][CH2:14][CH3:15]

参加物

6

反応物 5

HCID 227Anthranilic AcidHCID 312ChlorideHCID 313Hydrochloric AcidHCID 1049PyridineHCID 8028Tetrahydrofuran2 回

生成物 1

HCID 41572202-(Octanoylamino)benzoic acid収率 79.4%

実験手順

Anthranilic acid was dissolved in a mixed solvent containing pyridine and tetrahydrofuran (THF) in 5:5 ratio and a THF solution of n-caprioyl chloride was dropped to the solution during several hours for reaction. After the reaction, hydrochloric acid was added to the reaction mixture. Pyridine hydrochloride was filtered and the solvent was removed. N-n-octanoylanthranilic acid was obtained from the remaining reactant after the purification by column chromatography with the yield of 79.4%.

後処理

  1. additionwas added to the reaction mixture
  2. filtrationPyridine hydrochloride was filtered
  3. customthe solvent was removed

出典と根拠

ORDレコード
ord-26de8cb6b8ab4be3a4b1393e37538166
出典データセット
uspto-grants-1995_05
特許番号
US05413794

関連ノート

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