Sodium Carbonate → 1-Benzylindol-3-yl-n-[6-(1-methylpiperidin-4-ylcarbonyl)-pyridin-2-yl]-carboxamide

HRID 404232

反応式

HRID 404232 の反応式
C(Cl)(=O)C(Cl)=O.[CH2:7]([N:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16]([C:23]([OH:25])=O)=[CH:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[NH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([CH:35]2[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]2)=[O:34])[N:28]=1.C([O-])([O-])=O.[Na+].[Na+]>N1C=CC=CC=1.CC#N.C(Cl)(Cl)Cl>[CH2:7]([N:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16]([C:23]([NH:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([CH:35]3[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]3)=[O:34])[N:28]=2)=[O:25])=[CH:15]1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

参加物

8

反応物 4

HCID 10340Sodium CarbonateHCID 336711-benzyl-1H-indole-3-carboxylic acidHCID 65578Oxalyl chlorideHCID 11401723(6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone

生成物 1

HCID 597893621-Benzylindol-3-yl-n-[6-(1-methylpiperidin-4-ylcarbonyl)-pyridin-2-yl]-carboxamide収率 51.2%

試薬・触媒・溶媒 3

HCID 1049Pyridine溶媒2 回HCID 6212Chloroform溶媒HCID 6342Acetonitrile溶媒2 回

実験手順

Add oxalyl chloride (0.18 mL, 2.1 mmol) dropwise to a solution of 1-benzylindol-3-carboxylic acid (0.48 g, 1.9 mmol) in pyridine and CH3CN (5 mL each) cooled in an ice bath. Stir the reaction mixture for 2.25 hr. and then add a suspension of 2-amino-6-(1-methylpiperidin-4-ylcarbonyl)pyridine (0.56 g, 1.9 mmol) in CH3CN (5 mL) and pyridine (12 mL). Warm the reaction mixture to room temperature overnight. Quench the reaction with cold H2O (20 mL) and dilute with CHCl3. Adjust the pH to 11 with Na2CO3 and separate the layers. Extract the aqueous layer with CHCl3 (2×30 mL). Combine the organic fractions and dry with anhydrous MgSO4, filter and concentrate the mixture in vacuo. Purify the product by chromatography on a silica gel column, eluting with methanol/CH2Cl2 (5:95) followed by methanol/CH2Cl2 (10:90) to afford the sub-title compound (0.44 g, 51%). 1H NMR (CD3OD) 8.45 (d, J=8 Hz, 1H), 8.32 (s, 1H), 8.26 (m, 1H), 7.95 (t, J=8 Hz, 1H), 7.72 (d, J=8 Hz, 1H), 7.45 (m, 1H), 7.22-7.37 (m, 7H), 5.51 (s, 2H), 3.90 (m, 1H), 2.93-3.01 (m, 2H), 2.33 (s, 3H), 2.21-2.31 (m, 2H), 1.92-1.99 (m, 2H), 1.71-1.84 (m, 2H); CIMS (Methane) m/z 453 [C28H28N4O2+H]+.

後処理

  1. temperaturecooled in an ice bath
  2. additionand then add
  3. customQuench
  4. customthe reaction with cold H2O (20 mL)
  5. customseparate the layers
  6. extractionExtract the aqueous layer with CHCl3 (2×30 mL)
  7. dry with materialCombine the organic fractions and dry with anhydrous MgSO4
  8. filtrationfilter
  9. concentrationconcentrate the mixture in vacuo
  10. customPurify the product by chromatography on a silica gel column
  11. washeluting with methanol/CH2Cl2 (5:95)

出典と根拠

ORDレコード
ord-f72ab836894148299e348a18037649a0
出典データセット
uspto-grants-2014_06
特許番号
US08748459B2

関連ノート

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