Dimethyl Sulfoxide → 2-Amino-4-(p-chlorophenyl)-6-(methylthio)-pyrimidine-5-carbonitrile

HRID 1355692

반응식

HRID 1355692 반응식
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([CH2:8][C:9]#[N:10])=O)=[CH:4][CH:3]=1.[H-].[Na+].CI.[N+]([O-])(O)=O.[NH2:21][C:22]([NH2:24])=[NH:23].[CH3:25][S:26]([CH3:28])=O>CN(C=O)C.C(N(CC)CC)C.C(=S)=S>[NH2:23][C:22]1[N:24]=[C:6]([C:5]2[CH:11]=[CH:12][C:2]([Cl:1])=[CH:3][CH:4]=2)[C:8]([C:9]#[N:10])=[C:25]([S:26][CH3:28])[N:21]=1

참가 물질

9

반응물 5

HCID 679Dimethyl SulfoxideHCID 6328Methyl iodideHCID 10481Guanidine NitrateHCID 24758Sodium hydrideHCID 1383084-Chlorobenzoylacetonitrile

생성물 1

HCID 41388442-Amino-4-(p-chlorophenyl)-6-(methylthio)-pyrimidine-5-carbonitrile

시약·촉매·용매 3

HCID 6228Dimethylformamide용매HCID 6348Carbon Disulfide용매HCID 8471Triethylamine용매

실험 절차

From 4-chlorobenzoylacetonitrile with sodium hydride, carbon disulphide and methyl iodide in DMSO. Then treatment with guanidine nitrate and triethylamine in DMF. EI-MS m/e (%): 278 (M{37Cl}+, 14), 277 ([M{37Cl}—H]+, 42), 276 (M{35Cl} +, 46), 275 ([M{35Cl}—H]+, 100), 241 ([M—Cl]+, 30).

출처 및 근거

ORD 기록
ord-709d3ddd72b44eba933f13289e622e6d
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586441B2

연결된 노트

불러오는 중…