Dimethyl Sulfoxide → 2-Amino-4-(p-chlorophenyl)-6-(methylthio)-pyrimidine-5-carbonitrile
반응식
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([CH2:8][C:9]#[N:10])=O)=[CH:4][CH:3]=1.[H-].[Na+].CI.[N+]([O-])(O)=O.[NH2:21][C:22]([NH2:24])=[NH:23].[CH3:25][S:26]([CH3:28])=O>CN(C=O)C.C(N(CC)CC)C.C(=S)=S>[NH2:23][C:22]1[N:24]=[C:6]([C:5]2[CH:11]=[CH:12][C:2]([Cl:1])=[CH:3][CH:4]=2)[C:8]([C:9]#[N:10])=[C:25]([S:26][CH3:28])[N:21]=1참가 물질
9
실험 절차
From 4-chlorobenzoylacetonitrile with sodium hydride, carbon disulphide and methyl iodide in DMSO. Then treatment with guanidine nitrate and triethylamine in DMF. EI-MS m/e (%): 278 (M{37Cl}+, 14), 277 ([M{37Cl}—H]+, 42), 276 (M{35Cl} +, 46), 275 ([M{35Cl}—H]+, 100), 241 ([M—Cl]+, 30).
출처 및 근거
- ORD 기록
- ord-709d3ddd72b44eba933f13289e622e6d
- 출처 데이터셋
- uspto-grants-2003_07
- 특허 번호
- US06586441B2
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