Hydrochloric Acid → N-(4-benzoylphenyl)acetamide

HRID 1605171

반응식

HRID 1605171 반응식
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[Cl-].[Al+3].[Cl-].[Cl-].ClC(Cl)C.[C:19](Cl)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.Cl>>[C:19]([C:8]1[CH:9]=[CH:10][C:5]([NH:4][C:1](=[O:3])[CH3:2])=[CH:6][CH:7]=1)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

6

반응물 5

HCID 313Hydrochloric AcidHCID 904AcetanilideHCID 63651,1-DichloroethaneHCID 7412Benzoyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 228532N-(4-benzoylphenyl)acetamide

반응 조건

온도
80 °C

실험 절차

An ice-cooled solution of 5 grams of acetanilide and 15 g. of aluminum chloride in 75 ml. of dichloroethane is treated with 5 g. of benzoyl chloride in portions. The mixture is then heated at 80° C for 3 hours, decomposed with ice and dilute hydrochloric acid and the resulting solid isolated by suction filtration and recrystallized from ethanol:water to give p-benzoylacetanilide.

후처리

  1. customthe resulting solid isolated by suction filtration
  2. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-7671b3111bdd4df8ac7ebec234f49312
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03949084

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