Hydrochloric Acid → Cephalexin

HRID 914651

반응식

HRID 914651 반응식
[CH3:1][C:2]1[CH2:11][S:10][C@@H:5]2[C@H:6]([NH2:9])[C:7](=[O:8])[N:4]2[C:3]=1[C:12]([OH:14])=[O:13].[CH:15]1[CH:20]=[CH:19][C:18]([CH:21]([NH2:25])[C:22](N)=[O:23])=[CH:17][CH:16]=1.CC1(C)S[C@@H]2[C@H](NC(CC3C=CC=CC=3)=O)C(=O)N2[C@H]1C([O-])=O.[K+].Cl>>[CH3:1][C:2]1[CH2:11][S:10][C@@H:5]2[C@H:6]([NH:9][C:22]([C@H:21]([NH2:25])[C:18]3[CH:17]=[CH:16][CH:15]=[CH:20][CH:19]=3)=[O:23])[C:7](=[O:8])[N:4]2[C:3]=1[C:12]([OH:14])=[O:13]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 127912-Amino-2-phenylacetamideHCID 334987-Aminodeacetoxycephalosporanic acidHCID 23664709Penicillin G Potassium

생성물 1

HCID 27447Cephalexin

실험 절차

The reaction is carried out at 25° C. and pH 7.5 in a fixed bed reactor. 10 ml of an aqueous solution of a mixture 0.2 M 7-ADCA and 0.2 M D-phenylglycinamide are passed through a column with 0.5 ml of the immobilized penicillin amidase. During the reaction, the pH is kept constant by adding HCl in an attached stirred reservoir container. Samples are taken and analyzed by HPLC as shown in example 5 at particular time intervals.

후처리

  1. customis carried out at 25° C.
  2. customDuring the reaction

출처 및 근거

ORD 기록
ord-76ae13ba93db4ce78e8e70f1e9a58fcd
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07264943B2

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