DL-cysteine → HCID 512839, compound

HRID 1016520Notes

Reaction equation

HRID 1016520 reaction equation
[NH2:1][CH:2]([C:5]([OH:7])=[O:6])[CH2:3][SH:4].[CH2:8]([N:17]1[C:22](=[O:23])[CH2:21][C:19](=[CH2:20])[C:18]1=[O:24])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].C(N(CC)CC)C.C1C=C2C(C(O)(O)C(=O)C2=CC=1)=O>C([O-])(=O)C.[K+].CN(C)C=O.O.CO>[NH2:1][CH:2]([CH2:3][S:4][C:19]1([CH3:20])[CH2:21][C:22](=[O:23])[N:17]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:18]1=[O:24])[C:5]([OH:7])=[O:6]

Participants

9

Reactant 4

HCID 594DL-cysteineHCID 8471TriethylamineHCID 10236NinhydrinHCID 512825HCID 512825, compound

Product 1

HCID 512839HCID 512839, compound

Reagents, catalysts & solvents 4

HCID 887MethanolSolventHCID 962WaterSolventHCID 6228DimethylformamideSolventHCID 517044Potassium AcetateSolvent

Procedure

DL-Cysteine (0.0067 M) was dissolved in potassium acetate (50 mM) and the solution obtained was added slowly to N-nonyl itaconimide (0.004 M) prepared as described in Example 6 above. The reaction mixture was then dissolved in dimethylformamide with gentle stirring and triethylamine was added. Stirring was continued for a further four hours at room temperature. The progress of the reaction was monitored by reverse phase thin layer chromatography using 75% methanol in water system. The formation of the desired product was detected by the ninhydrin reaction.

Workup

  1. customthe solution obtained
  2. customprepared
  3. stirringStirring

Sources & evidence

ORD record
ord-25a58d3e42574e0c948104ae32a2b777
Source dataset
uspto-grants-2002_11
Patent number
US06476053B1

Reaction notes

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