1,2-Dichloroethane → N-(3-Chloro-6-fluoro-1H-indazol-5-yl)-4-(4-chloro-2-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide

HRID 101779Notes

Reaction equation

HRID 101779 reaction equation
[CH2:32]([Cl:33])[CH2:34][Cl:35].[CH3:36][CH2:37][N:38]([CH2:39][CH3:40])[CH2:41][CH3:42].[CH3:48][CH2:49][O:50][C:51]([CH3:52])=[O:53].[Cl:1][c:2]1[cH:3][c:4]([F:19])[c:5]([CH:8]2[C:9]([C:16](=[O:17])[OH:18])=[C:10]([CH3:15])[NH:11][C:12](=[O:14])[CH2:13]2)[cH:6][cH:7]1.[Cl:20][c:21]1[n:22][nH:23][c:24]2[cH:25][c:26]([F:31])[c:27]([NH2:30])[cH:28][c:29]12.[ClH:54].[O:43]=[CH:44][N:45]([CH3:46])[CH3:47]>>[Cl:1][c:2]1[cH:3][c:4]([F:19])[c:5]([CH:8]2[C:9]([C:16](=[O:18])[NH:30][c:27]3[c:26]([F:31])[cH:25][c:24]4[nH:23][n:22][c:21]([Cl:20])[c:29]4[cH:28]3)=[C:10]([CH3:15])[NH:11][C:12](=[O:14])[CH2:13]2)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 111,2-DichloroethaneHCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 688260574-(4-Chloro-2-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylic acidHCID 1785072033-chloro-6-fluoro-1H-indazol-5-amine

Product 1

HCID 178429202N-(3-Chloro-6-fluoro-1H-indazol-5-yl)-4-(4-chloro-2-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide

Sources & evidence

ORD record
ord-71d424617bba40f298434d78549f3fd1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…