1-Phenylpiperazine → HCID 14763445, compound

HRID 1087819Notes

Reaction equation

HRID 1087819 reaction equation
CN(C)C[CH2:4][CH2:5][NH:6][C:7]([N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)=[O:8].C(N1C=CN=C1)(N1C=CN=C1)=O.NCC[N:37]1[CH2:42][CH2:41][CH2:40][CH2:39][CH2:38]1.C1(N2CCNCC2)C=CC=CC=1>O1CCCC1>[C:15]1([N:12]2[CH2:11][CH2:10][N:9]([C:7]([NH:6][CH2:5][CH2:4][N:37]3[CH2:42][CH2:41][CH2:40][CH2:39][CH2:38]3)=[O:8])[CH2:14][CH2:13]2)[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

6

Reactant 4

HCID 70961-PhenylpiperazineHCID 33944N-(2-Aminoethyl)piperidineHCID 682631,1'-CarbonyldiimidazoleHCID 14763436HCID 14763436, compound

Product 1

HCID 14763445HCID 14763445, compoundYield 24%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound was prepared according to the procedure used to synthesize the compound of Example 5. A mixture of 5.7 g (0.035 mole) of 1,1'-carbonyldiimidazole, 4.4 g (0.034 mole) of N-(2-aminoethyl)piperidine and 4.9 g (0.03 mole) of 1-phenylpiperazine in a total of 200 ml of tetrahydrofuran gave 2.3 g (24%) of title compound as a white solid, m.p. 64°-67° C. after recrystallization from diethyl ether.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-f0b15ced04834c73b75792e627988288
Source dataset
uspto-grants-1990_10
Patent number
US04960776

Reaction notes

Loading…