6-Quinolinyl trifluoromethanesulfonate → HCID 178422846, compound

HRID 1100680Notes

Reaction equation

HRID 1100680 reaction equation
Cc1ccc2c(cnn2C2CCCCO2)c1B(O)O.O=S(=O)(Oc1ccc2ncccc2c1)C(F)(F)F>C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.C1CCOC1.CC(=O)[O-].CC(=O)[O-].CCc1cc(CC)cc(CC)c1.CCc1cccc(CC)c1.CN(C)C=O.Cc1ccccc1.O.[Pd+2]>Cc1ccc2c(cnn2C2CCCCO2)c1-c1ccc2ncccc2c1

Participants

12

Reactant 2

HCID 152903586-Quinolinyl trifluoromethanesulfonateHCID 129009568[5-Methyl-1-(oxan-2-yl)-1H-indazol-4-yl]boronic acid

Product 1

HCID 178422846HCID 178422846, compoundYield 75.64%

Reagents, catalysts & solvents 9

HCID 75806TricyclohexylphosphineCatalystHCID 167845palladium(II) acetateCatalystHCID 962WaterSolvent2×HCID 1140TolueneSolventHCID 6228DimethylformamideSolventHCID 76021,3,5-TriethylbenzeneSolventHCID 8028TetrahydrofuranSolventHCID 88641,3-DiethylbenzeneSolventHCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-a42233be58cf4995ac239e969a55252c
Source dataset
Rapid material-sparing screening of 5760 Suzuki-Miyaura coupling reactions
Original link
View source

Reaction notes

Loading…