6-Quinolinyl trifluoromethanesulfonate → HCID 178422846, compound

HRID 1102922Notes

Reaction equation

HRID 1102922 reaction equation
Cc1ccc2c(cnn2C2CCCCO2)c1[B-](F)(F)F.O=S(=O)(Oc1ccc2ncccc2c1)C(F)(F)F.[K+]>C1CCOC1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(C(C)(C)C)C(C)(C)C.CCc1cc(CC)cc(CC)c1.CCc1cccc(CC)c1.CN(C)C=O.Cc1ccccc1.O.[K+].[OH-].[Pd+2]>Cc1ccc2c(cnn2C2CCCCO2)c1-c1ccc2ncccc2c1

Participants

13

Reactant 2

HCID 152903586-Quinolinyl trifluoromethanesulfonateHCID 178422845HCID 178422845, compound

Product 1

HCID 178422846HCID 178422846, compoundYield 14.49%

Reagents, catalysts & solvents 10

HCID 14797Potassium HydroxideReagentHCID 83681Tris(1,1-dimethylethyl)phosphineCatalystHCID 167845palladium(II) acetateCatalystHCID 962WaterSolvent2×HCID 1140TolueneSolventHCID 6228DimethylformamideSolventHCID 76021,3,5-TriethylbenzeneSolventHCID 8028TetrahydrofuranSolventHCID 88641,3-DiethylbenzeneSolventHCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-598ee3b65e4b4274bc5126ec9d9c2007
Source dataset
Rapid material-sparing screening of 5760 Suzuki-Miyaura coupling reactions
Original link
View source

Reaction notes

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