Hydrochloric Acid → 4-Difluoromethoxymethyl-pyrrolidine-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester

HRID 1116269Notes

Reaction equation

HRID 1116269 reaction equation
[Br:25][CH2:26][C:27](=[O:28])[c:29]1[cH:30][cH:31][c:32]([Br:35])[cH:33][cH:34]1.[CH3:1][O:2][C:3](=[O:4])[CH:5]1[N:6]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:7][CH:8]([CH2:10][O:11][CH:12]([F:13])[F:14])[CH2:9]1.[CH3:36][CH2:37][N:38]([CH2:39][CH3:40])[CH2:41][CH3:42].[CH3:43][OH:44].[ClH:24].[Li+:23].[OH-:22]>>[CH2:1]([O:2][C:3](=[O:4])[CH:5]1[N:6]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:7][CH:8]([CH2:10][O:11][CH:12]([F:13])[F:14])[CH2:9]1)[C:27](=[O:28])[c:29]1[cH:30][cH:31][c:32]([Br:35])[cH:33][cH:34]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 887MethanolHCID 961HydroxideHCID 74544-Bromophenacyl bromideHCID 8471TriethylamineHCID 28486Lithium ionHCID 666204384-Difluoromethoxymethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Product 1

HCID 667889894-Difluoromethoxymethyl-pyrrolidine-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester

Sources & evidence

ORD record
ord-a0149e2004cf4ba4a57dd73d51a3bac1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…