Tetrahydrofuran → N-{5-[(2-Chloro-4-pyrimidinyl)ethynyl]-2-methylphenyl}-2,2,2-trifluoroacetamide

HRID 1117012Notes

Reaction equation

HRID 1117012 reaction equation
[C:9](#[CH:10])[c:11]1[cH:12][cH:13][c:14]([CH3:24])[c:15]([NH:17][C:18]([C:19]([F:20])([F:21])[F:22])=[O:23])[cH:16]1.[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1.[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([Cl:8])[n:7]1.[Cu:71][I:72].[Pd:30]([Cl:31])[Cl:32].[c:33]1([P:34]([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[cH:47][cH:48][cH:49][cH:50][cH:51]1.[c:52]1([P:53]([c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)[c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[cH:66][cH:67][cH:68][cH:69][cH:70]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:10]#[C:9][c:11]2[cH:12][cH:13][c:14]([CH3:24])[c:15]([NH:17][C:18]([C:19]([F:20])([F:21])[F:22])=[O:23])[cH:16]2)[n:7]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 775312,4-DichloropyrimidineHCID 57737207N-(5-Ethynyl-2-methylphenyl)-2,2,2-trifluoroacetamide

Product 1

HCID 57737211N-{5-[(2-Chloro-4-pyrimidinyl)ethynyl]-2-methylphenyl}-2,2,2-trifluoroacetamide

Sources & evidence

ORD record
ord-6bf38d991f084cc1a80304a9e82423e1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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