Acetic Acid → 2-Bromo-6-fluorobenzaldehyde

HRID 1124149Notes

Reaction equation

HRID 1124149 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:8])[cH:5][cH:6][cH:7]1.[CH2:30]1[CH2:32][CH2:31][CH2:33][O:34]1.[CH3:36][O:37][C:38]([CH3:39])([CH3:40])[CH3:41].[CH3:42][C:43](=[O:44])[OH:45].[CH:22]([NH:23][CH:24]([CH3:25])[CH3:26])([CH3:27])[CH3:28].[CH:9]([N-:10][CH:11]([CH3:12])[CH3:13])([CH3:14])[CH3:15].[ClH:29].[Li+:16].[Li:17][CH2:18][CH2:19][CH2:20][CH3:21].[O:46]=[CH:47][N:48]([CH3:49])[CH3:50].[OH2:35]>>[Br:1][c:2]1[c:3]([CH:33]=[O:34])[c:4]([F:8])[cH:5][cH:6][cH:7]1

Participants

12

Reactant 11

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 962WaterHCID 6228DimethylformamideHCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 140821-Bromo-3-fluorobenzeneHCID 15413tert-Butyl methyl etherHCID 28486Lithium ionHCID 5062348DiisopropylamideHCID 178418339Butyllithium

Product 1

HCID 224739772-Bromo-6-fluorobenzaldehyde

Sources & evidence

ORD record
ord-d5c9653f341d415b965caa5d105cadda
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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