Dimethylformamide → 1-(3-chloro-2-pyridinyl)-N-[2-methyl-6-[2-[(1-methylethyl)amino]-2-oxoethyl]phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

HRID 1138810Notes

Reaction equation

HRID 1138810 reaction equation
[CH3:53][N:54]([CH3:55])[c:56]1[cH:57][cH:58][n:59][cH:60][cH:61]1.[CH3:67][N:68]([CH3:69])[CH:70]=[O:71].[CH:41]([N:42]([CH2:43][CH3:44])[CH:45]([CH3:46])[CH3:47])([CH3:48])[CH3:49].[Cl:1][c:2]1[c:3](-[n:8]2[n:9][c:10]([C:16]([F:17])([F:18])[F:19])[cH:11][c:12]2[C:13](=[O:14])[OH:15])[n:4][cH:5][cH:6][cH:7]1.[Cl:20][C:21]([C:22]([Cl:23])=[O:24])=[O:25].[Cl:50][CH2:51][Cl:52].[NH2:26][c:27]1[c:28]([CH2:34][C:35](=[O:36])[NH:37][CH:38]([CH3:39])[CH3:40])[cH:29][cH:30][cH:31][c:32]1[CH3:33].[O:62]1[CH2:63][CH2:64][CH2:65][CH2:66]1>>[Cl:1][c:2]1[c:3](-[n:8]2[n:9][c:10]([C:16]([F:17])([F:18])[F:19])[cH:11][c:12]2[C:13](=[O:15])[NH:26][c:27]2[c:28]([CH2:34][C:35](=[O:36])[NH:37][CH:38]([CH3:39])[CH3:40])[cH:29][cH:30][cH:31][c:32]2[CH3:33])[n:4][cH:5][cH:6][cH:7]1

Participants

9

Reactant 8

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 142844-(Dimethylamino)pyridineHCID 65578Oxalyl chlorideHCID 81531DiisopropylethylamineHCID 113921841-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acidHCID 673906992-amino-3-methyl-N-(1-methylethyl)benzeneacetamide

Product 1

HCID 160977431-(3-chloro-2-pyridinyl)-N-[2-methyl-6-[2-[(1-methylethyl)amino]-2-oxoethyl]phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Sources & evidence

ORD record
ord-b0852bb5a9364d93aa8f937477a3fd2a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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