Hydrochloric Acid → tert-Butyl (4-(methoxy(methyl)carbamoyl)thiazol-2-yl)carbamate

HRID 1148379Notes

Reaction equation

HRID 1148379 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][c:9]1[s:10][cH:11][c:12]([C:14](=[O:15])[OH:16])[n:13]1.[CH3:18][NH:19][O:20][CH3:21].[CH3:23][N:24]([CH3:25])[CH2:26][CH2:27][CH2:28][N:29]=[C:30]=[N:31][CH2:32][CH3:33].[CH3:45][CH2:46][N:47]([CH2:48][CH3:49])[CH2:50][CH3:51].[CH3:52][N:53]([CH3:54])[c:55]1[cH:56][cH:57][n:58][cH:59][cH:60]1.[CH3:64][CH2:65][O:66][C:67](=[O:68])[CH3:69].[Cl:61][CH2:62][Cl:63].[ClH:17].[ClH:22].[OH2:34].[OH:35][n:36]1[c:37]2[cH:38][cH:39][cH:40][cH:41][c:42]2[n:43][n:44]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][c:9]1[s:10][cH:11][c:12]([C:14](=[O:16])[N:19]([CH3:18])[O:20][CH3:21])[n:13]1

Participants

11

Reactant 10

HCID 313Hydrochloric Acid2×HCID 962WaterHCID 6344DichloromethaneHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 14232N,O-DimethylhydroxylamineHCID 142844-(Dimethylamino)pyridineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 15020512-Amino-1,3-thiazole-4-carboxylic acid, N-BOC protected

Product 1

HCID 58604314tert-Butyl (4-(methoxy(methyl)carbamoyl)thiazol-2-yl)carbamate

Sources & evidence

ORD record
ord-93d7617421df4740a3fbbfc58e4ef214
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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