Acetate → Methyl 3-(3-fluoro-4-hydroxyphenyl)prop-2-enoate

HRID 1149654Notes

Reaction equation

HRID 1149654 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:9])[c:5]([OH:8])[cH:6][cH:7]1.[C:10]([CH:11]=[CH2:12])(=[O:13])[O:14][CH3:15].[CH3:16][CH2:17][N:18]([CH2:19][CH3:20])[CH2:21][CH3:22].[CH3:50][CH2:51][O:52][C:53]([CH3:54])=[O:55].[O-:57][C:58]([CH3:59])=[O:60].[O-:61][C:62]([CH3:63])=[O:64].[O:45]=[CH:46][N:47]([CH3:48])[CH3:49].[Pd+2:56].[c:23]1([CH3:24])[cH:25][cH:26][cH:27][cH:28][c:29]1[P:30]([c:31]1[cH:32][cH:33][cH:34][cH:35][c:36]1[CH3:37])[c:38]1[cH:39][cH:40][cH:41][cH:42][c:43]1[CH3:44]>>[c:2]1([CH:12]=[CH:11][C:10](=[O:13])[O:14][CH3:15])[cH:3][c:4]([F:9])[c:5]([OH:8])[cH:6][cH:7]1

Participants

9

Reactant 8

HCID 175Acetate2×HCID 6228DimethylformamideHCID 7294Methyl AcrylateHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 80271Tri-o-tolylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27249814-Bromo-2-fluorophenol

Product 1

HCID 71412305Methyl 3-(3-fluoro-4-hydroxyphenyl)prop-2-enoate

Sources & evidence

ORD record
ord-9c0e8ee8ba4a4ef2bfdf360ac8dcd3f1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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