Hydrochloric Acid → 4-(4-Chloro-2-fluoroanilino)-6-methoxy-7-(3-(4-methylpiperazin-1-ylcarbonyl)propoxy)quinazoline
Reaction equation
[C:13](=[O:14])([OH:15])[CH2:16][CH2:17][CH2:18][O:19][c:20]1[c:21]([O:39][CH3:40])[cH:22][c:23]2[c:24]([NH:30][c:31]3[c:32]([F:38])[cH:33][c:34]([Cl:37])[cH:35][cH:36]3)[n:25][cH:26][n:27][c:28]2[cH:29]1.[CH3:2][N:3]([CH3:4])[CH2:5][CH2:6][CH2:7][N:8]=[C:9]=[N:10][CH2:11][CH3:12].[CH3:41][N:42]1[CH2:43][CH2:44][NH:45][CH2:46][CH2:47]1.[CH3:48][N:49]([CH3:50])[c:51]1[cH:52][cH:53][n:54][cH:55][cH:56]1.[ClH:1].[O:57]=[CH:58][N:59]([CH3:60])[CH3:61]>>[C:13](=[O:15])([CH2:16][CH2:17][CH2:18][O:19][c:20]1[c:21]([O:39][CH3:40])[cH:22][c:23]2[c:24]([NH:30][c:31]3[c:32]([F:38])[cH:33][c:34]([Cl:37])[cH:35][cH:36]3)[n:25][cH:26][n:27][c:28]2[cH:29]1)[N:45]1[CH2:44][CH2:43][N:42]([CH3:41])[CH2:47][CH2:46]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-53b3a4f466874c5d9c3c1031816beee9
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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