1,2-Dichloroethane → 4-(4-fluorophenyl)-N-1H-indazol-5-yl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide

HRID 1217104Notes

Reaction equation

HRID 1217104 reaction equation
[CH2:29]([Cl:30])[CH2:31][Cl:32].[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[CH3:40][N:41]([c:42]1[cH:43][cH:44][n:45][cH:46][cH:47]1)[CH3:48].[CH3:50][CH2:51][O:52][C:53](=[O:54])[CH3:55].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[NH:9][C:10](=[O:18])[NH:11][CH:12]=[C:13]2[C:14]([O:16][CH3:15])=[O:17])[cH:6][cH:7]1.[NH2:19][c:20]1[cH:21][c:22]2[cH:23][n:24][nH:25][c:26]2[cH:27][cH:28]1.[O:56]=[CH:57][N:58]([CH3:59])[CH3:60].[OH2:49]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[NH:9][C:10](=[O:18])[NH:11][CH:12]=[C:13]2[C:14](=[O:16])[NH:19][c:20]2[cH:21][c:22]3[cH:23][n:24][nH:25][c:26]3[cH:27][cH:28]2)[cH:6][cH:7]1

Participants

9

Reactant 8

HCID 111,2-DichloroethaneHCID 962WaterHCID 6228DimethylformamideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 142844-(Dimethylamino)pyridineHCID 880121H-Indazol-5-amineHCID 57755876Methyl 4-(4-fluorophenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Product 1

HCID 111755614-(4-fluorophenyl)-N-1H-indazol-5-yl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide

Sources & evidence

ORD record
ord-d44442b7677d4fc7974c0b3561315564
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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