Dimethylformamide → 1-(2,6-difluorophenyl)-7-[(2,4-difluorophenyl)ethynyl]-2H-quinolizin-2-one

HRID 1237953Notes

Reaction equation

HRID 1237953 reaction equation
[Br:1][c:2]1[cH:3][n:4]2[cH:5][cH:6][c:7](=[O:20])[c:8](-[c:12]3[c:13]([F:19])[cH:14][cH:15][cH:16][c:17]3[F:18])[c:9]2[cH:10][cH:11]1.[C:21](#[CH:22])[c:23]1[c:24]([F:30])[cH:25][c:26]([F:29])[cH:27][cH:28]1.[CH3:31][CH2:32][N:33]([CH2:34][CH3:35])[CH2:36][CH3:37].[CH3:43][CH2:44][O:45][C:46](=[O:47])[CH3:48].[Cu:49][I:50].[O:38]=[CH:39][N:40]([CH3:41])[CH3:42]>>[c:2]1([C:22]#[C:21][c:23]2[c:24]([F:30])[cH:25][c:26]([F:29])[cH:27][cH:28]2)[cH:3][n:4]2[cH:5][cH:6][c:7](=[O:20])[c:8](-[c:12]3[c:13]([F:19])[cH:14][cH:15][cH:16][c:17]3[F:18])[c:9]2[cH:10][cH:11]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 50638201-Ethynyl-2,4-difluorobenzeneHCID 575312307-bromo-1-(2,6-difluorophenyl)-2H-quinolizin-2-one

Product 1

HCID 167496341-(2,6-difluorophenyl)-7-[(2,4-difluorophenyl)ethynyl]-2H-quinolizin-2-one

Sources & evidence

ORD record
ord-6e333cf5b743458cae324317bde8e2a1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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