Hydrochloric Acid → Hexahydrofuro(2,3-b)furan-3-ol

To a stirred solution of compound (I.5, 0.011 mol, 2.4 g, syn/anti mixture) in isopropanol (20 ml), potassium tert-butoxide (0.0132 mol, 1.5 g) was added portionwise over 30 minutes at room temperature. The basic solution was transferred to an addition funnel and added dropwise over 10 minutes to a cooled (0° C.) vigorously stirred mixture of concentrated (37%) hydrochloric acid (0.0275 mol, 2.3 ml) in isopropanol (20 ml). The reaction mixture was stirred for 2 hours at room temperature, then triethylamine (0.022 mol, 2.2 g) was added dropwise causing Et3N.HCl salts to precipitate. The reaction mixture was diluted with ethyl acetate (50 ml) and filtered to remove the salts. The solvent was evaporated under reduced pressure. The residue was diluted with ethyl acetate (50 ml) causing more Et3N.HCl salts to precipitate. The salts were removed by filtration and the solvent was evaporated under reduced pressure. The residual oil was further purified by silica gel plug filtration with ethyl acetate as eluent to afford a mixture of compounds (7.1/7.2, 1.03 g, yield=72%) in a ratio of 78/22 (determined by 1H NMR). Analytical samples of the pure compounds (7.1, Rf7.1=0.27) and (7.2, Rf7.2=0.15) were obtained by means of silica gel chromatography using ethyl acetate as the solvent.

1. customThe basic solution was transferred to an addition funnel
2. additionadded dropwise over 10 minutes to
3. temperaturea cooled
4. addition(0° C.) vigorously stirred mixture
5. customto precipitate
6. additionThe reaction mixture was diluted with ethyl acetate (50 ml)
7. filtrationfiltered
8. customto remove the salts
9. customThe solvent was evaporated under reduced pressure
10. additionThe residue was diluted with ethyl acetate (50 ml)
11. customto precipitate
12. customThe salts were removed by filtration
13. customthe solvent was evaporated under reduced pressure
14. filtrationThe residual oil was further purified by silica gel plug filtration with ethyl acetate as eluent
15. customto afford
16. additiona mixture of compounds (7.1/7.2, 1.03 g, yield=72%) in a ratio of 78/22 (determined by 1H NMR)
17. customAnalytical samples of the pure compounds (7.1, Rf7.1=0.27) and (7.2, Rf7.2=0.15) were obtained by means of silica gel chromatography

ORD record

ord-5b42a44404f140bb99baf2cf019d53b5

Source dataset

uspto-grants-2006_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07126015B2