Hydrochloric Acid → 2-[[2-(3-Butoxy-phenyl)-ethyl]-(tetrahydrofuran-3-ylmethyl)amino]-N,N-dimethyl-acetamide hydrochloride

HRID 1261455Notes

Reaction equation

HRID 1261455 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][N:10]([CH2:17][CH:18]2[CH2:22][CH2:21][O:20][CH2:19]2)[CH2:11][C:12]([N:14]([CH3:16])[CH3:15])=[O:13])[CH:5]=[CH:6][CH:7]=1.Br[CH2:24][CH2:25][CH2:26][CH3:27].C(=O)([O-])[O-].[K+].[K+].[I].[K].[ClH:36]>CN(C=O)C.CCOC(C)=O.C(OCC)C>[ClH:36].[CH2:24]([O:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][N:10]([CH2:17][CH:18]2[CH2:22][CH2:21][O:20][CH2:19]2)[CH2:11][C:12]([N:14]([CH3:16])[CH3:15])=[O:13])[CH:5]=[CH:6][CH:7]=1)[CH2:25][CH2:26][CH3:27]

Participants

9

Reactant 5

HCID 313Hydrochloric AcidHCID 8002Butyl bromideHCID 11430Potassium CarbonateHCID 595968312-[[2-(3-hydroxy-phenyl)-ethyl]-(tetrahydrofuran-3-ylmethyl)amino]-N,N-dimethyl-acetamideHCID 178506587HCID 178506587, compound

Product 1

HCID 665912022-[[2-(3-Butoxy-phenyl)-ethyl]-(tetrahydrofuran-3-ylmethyl)amino]-N,N-dimethyl-acetamide hydrochlorideYield 50%

Reagents, catalysts & solvents 3

HCID 3283Diethyl EtherSolventHCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 2-[[2-(3-hydroxy-phenyl)-ethyl]-(tetrahydrofuran-3-ylmethyl)amino]-N,N-dimethyl-acetamide (1.0 g 3.3 mmol), 1-bromobutane (0.43 ml, 4 mmol), potassium carbonate (680 mg 5 mmol), potassium iodine (50 mg, 0.3 mmol), in DMF (30 ml) was refluxed for 16 h. After filtration over celite pad, the solution was evaporated from the solvent and the crude oil obtained purified by preparative HPLC. The hydrochloride salt was prepared by adding HCl 1N in AcOEt to the free amine dissolved in ethyl ether. After filtration, 690 mg (50% yield) the title compound was obtained as a white solid of 99% purity.

Workup

  1. filtrationAfter filtration over celite pad
  2. customthe solution was evaporated from the solvent
  3. customthe crude oil obtained
  4. custompurified by preparative HPLC
  5. filtrationAfter filtration

Sources & evidence

ORD record
ord-586e6707412e4dd082fc0a2248e12e56
Source dataset
uspto-grants-2013_06
Patent number
US08470877B2

Reaction notes

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