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HRID1282413

反应详情

EQUATION

反应方程式

HRID 1282413 的结构方程式

REACTANTS

反应物

5
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：O=C(C(F)(F)F)C(F)(F)F
HCID12695

Hexafluoroacetone

C3F6O

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：C#C[Si](C)(C)C
HCID66111

Trimethylsilylacetylene

C5H10Si

2 次

结构：[Li]CCCC
HCID178418339

Butyllithium

C4H9Li

PRODUCTS

生成物

1
结构：C1=Cc2ccccc2OC1
HCID9211

1,2-Benzopyran

C9H8O

AUXILIARIES

试剂、催化剂与溶剂

4
结构：[Cu][I]
催化剂HCID24350

Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

CuI

结构：O=S(=O)([O-])[O-].O=S(=O)([O-])[O-].[Ba+2].[Pd+2]
催化剂HCID17887766

未命名化合物

结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
催化剂HCID178418397

未命名化合物

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

According to Tetrahedron Letters, 1993, 34, 1815-1818, a compound (IIf) and trimethylsilyl acetylene are subjected to cross-coupling reaction in the presence of copper(I) iodide and tetrakis(triphenylphosphine)palladium and the resulting trimethylsilyl acetylene compound is treated with potassium carbonate in methanol to give a compound represented by the formula (XIX) set forth below. This compound is reacted with hexafluoroacetone using n-butyllithium to give a compound represented by the formula (XX). This compound is reduced with a palladium-barium sulfate catalyst under a hydrogen atmosphere to give a compound represented by the formula (XXI). This compound is reacted with sodium hydride to give a benzopyran derivative represented by the formula (XXII).

WORKUP

后处理

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